Reduced Warburg Effect in Cancer Cells Undergoing Autophagy: Steady- State 1H-MRS and Real-Time Hyperpolarized 13C-MRS Studies

Gigin Lin; Gabriela Andrejeva; Anne-Christine Wong Te Fong; Deborah K. Hill; Matthew R. Orton; Harry G. Parkes; Dow-Mu Koh; Simon P. Robinson; Martin O. Leach; Thomas R. Eykyn; Yuen-Li Chung

doi:10.1371/journal.pone.0092645

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Open Access

Peer-reviewed

Research Article

Reduced Warburg Effect in Cancer Cells Undergoing Autophagy: Steady- State ¹H-MRS and Real-Time Hyperpolarized ¹³C-MRS Studies

Gigin Lin ,

Contributed equally to this work with: Gigin Lin, Gabriela Andrejeva

Affiliations Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom, Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, College of Medicine, Chang Gung University, Taoyuan, Taiwan
⨯
Gabriela Andrejeva ,

Contributed equally to this work with: Gigin Lin, Gabriela Andrejeva

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯
Anne-Christine Wong Te Fong,

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯
Deborah K. Hill,

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯
Matthew R. Orton,

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯
Harry G. Parkes,

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯
Dow-Mu Koh,

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯
Simon P. Robinson,

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯
Martin O. Leach ,

* E-mail: ylichung@icr.ac.uk (YLC); Martin.Leach@icr.ac.uk (MOL)

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯
Thomas R. Eykyn,

Affiliations Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom, Division of Imaging Sciences and Biomedical Engineering, King′s College London, The Rayne Institute, St Thomas Hospital, London, United Kingdom
⨯
Yuen-Li Chung

* E-mail: ylichung@icr.ac.uk (YLC); Martin.Leach@icr.ac.uk (MOL)

Affiliation Cancer Research UK and EPSRC Cancer Imaging Centre, Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden Hospital, Sutton, Surrey, United Kingdom
⨯

Reduced Warburg Effect in Cancer Cells Undergoing Autophagy: Steady- State ¹H-MRS and Real-Time Hyperpolarized ¹³C-MRS Studies

Gigin Lin,
Gabriela Andrejeva,
Anne-Christine Wong Te Fong,
Deborah K. Hill,
Matthew R. Orton,
Harry G. Parkes,
Dow-Mu Koh,
Simon P. Robinson,
Martin O. Leach,
Thomas R. Eykyn

Published: March 25, 2014
https://doi.org/10.1371/journal.pone.0092645

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