The Construction of Risk Prediction Models Using GWAS Data and Its Application to a Type 2 Diabetes Prospective Cohort

Daichi Shigemizu; Testuo Abe; Takashi Morizono; Todd A. Johnson; Keith A. Boroevich; Yoichiro Hirakawa; Toshiharu Ninomiya; Yutaka Kiyohara; Michiaki Kubo; Yusuke Nakamura; Shiro Maeda; Tatsuhiko Tsunoda

doi:10.1371/journal.pone.0092549

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Open Access

Peer-reviewed

Research Article

The Construction of Risk Prediction Models Using GWAS Data and Its Application to a Type 2 Diabetes Prospective Cohort

Daichi Shigemizu,

Affiliation Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⨯
Testuo Abe,

Affiliation Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⨯
Takashi Morizono,

Affiliation Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⨯
Todd A. Johnson,

Affiliation Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⨯
Keith A. Boroevich,

Affiliation Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⨯
Yoichiro Hirakawa,

Affiliation Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Toshiharu Ninomiya,

Affiliations Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Yutaka Kiyohara,

Affiliation Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
⨯
Michiaki Kubo,

Affiliation Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⨯
Yusuke Nakamura,

Affiliation Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⨯
Shiro Maeda,

Affiliation Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⨯
Tatsuhiko Tsunoda

* E-mail: tsunoda@src.riken.jp

Affiliation Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
⨯

The Construction of Risk Prediction Models Using GWAS Data and Its Application to a Type 2 Diabetes Prospective Cohort

Daichi Shigemizu,
Testuo Abe,
Takashi Morizono,
Todd A. Johnson,
Keith A. Boroevich,
Yoichiro Hirakawa,
Toshiharu Ninomiya,
Yutaka Kiyohara,
Michiaki Kubo,
Yusuke Nakamura

Published: March 20, 2014
https://doi.org/10.1371/journal.pone.0092549

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Medical risk factors
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Forecasting
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Genetic predisposition
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Single nucleotide polymorphisms
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Type 2 diabetes
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Type 2 diabetes risk
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