Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents

Yusuke Oku; Chiaki Tareyanagi; Shinichi Takaya; Sayaka Osaka; Haruki Ujiie; Kentaro Yoshida; Naoyuki Nishiya; Yoshimasa Uehara

doi:10.1371/journal.pone.0092402

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Peer-reviewed

Research Article

Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents

Yusuke Oku,

Affiliation Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmaceutical Sciences, Yahaba-cho, Shiwa-gun, Iwate, Japan
⨯
Chiaki Tareyanagi,

Affiliation Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmaceutical Sciences, Yahaba-cho, Shiwa-gun, Iwate, Japan
⨯
Shinichi Takaya,

Affiliation Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmaceutical Sciences, Yahaba-cho, Shiwa-gun, Iwate, Japan
⨯
Sayaka Osaka,

Affiliation Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmaceutical Sciences, Yahaba-cho, Shiwa-gun, Iwate, Japan
⨯
Haruki Ujiie,

Affiliation Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmaceutical Sciences, Yahaba-cho, Shiwa-gun, Iwate, Japan
⨯
Kentaro Yoshida,

Affiliation Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmaceutical Sciences, Yahaba-cho, Shiwa-gun, Iwate, Japan
⨯
Naoyuki Nishiya,

Affiliation Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmaceutical Sciences, Yahaba-cho, Shiwa-gun, Iwate, Japan
⨯
Yoshimasa Uehara

* E-mail: yuehara@iwate-med.ac.jp

Affiliation Department of Microbial Chemical Biology and Drug Discovery, Iwate Medical University School of Pharmaceutical Sciences, Yahaba-cho, Shiwa-gun, Iwate, Japan
⨯

Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents

Yusuke Oku,
Chiaki Tareyanagi,
Shinichi Takaya,
Sayaka Osaka,
Haruki Ujiie,
Kentaro Yoshida,
Naoyuki Nishiya,
Yoshimasa Uehara

Published: March 18, 2014
https://doi.org/10.1371/journal.pone.0092402

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21 Mar 2014
01:38 GMT
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Figure 3 Posted by Yusukeoku on 21 Mar 2014 at 01:38 GMT

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