Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants

Sharath P. Sasi; Sanggyu Bae; Jin Song; Aleksandr Perepletchikov; Douglas Schneider; Joseph Carrozza; Xinhua Yan; Raj Kishore; Heiko Enderling; David A. Goukassian

doi:10.1371/journal.pone.0092373

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Peer-reviewed

Research Article

Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants

Sharath P. Sasi,

Affiliation Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America
⨯
Sanggyu Bae,

Affiliations Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America, Departments of Medicine and Pathology, Steward St. Elizabeth' Medical Center, Boston, Massachusetts, United States of America
⨯
Jin Song,

Affiliation Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America
⨯
Aleksandr Perepletchikov,

Affiliations Departments of Medicine and Pathology, Steward St. Elizabeth' Medical Center, Boston, Massachusetts, United States of America, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Douglas Schneider,

Affiliations Departments of Medicine and Pathology, Steward St. Elizabeth' Medical Center, Boston, Massachusetts, United States of America, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Joseph Carrozza,

Affiliations Departments of Medicine and Pathology, Steward St. Elizabeth' Medical Center, Boston, Massachusetts, United States of America, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Xinhua Yan,

Affiliations Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Raj Kishore,

Affiliation Feinberg Cardiovascular Institute, Northwestern University, Chicago, Illinois, United States of America
⨯
Heiko Enderling,

Affiliation Integrated Mathematical Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
David A. Goukassian

* E-mail: david.goukassian@tufts.edu

Affiliations Cardiovascular Research Center, GeneSys Research Institute, Boston, Massachusetts, United States of America, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯

Therapeutic Non-Toxic Doses of TNF Induce Significant Regression in TNFR2-p75 Knockdown Lewis Lung Carcinoma Tumor Implants

Sharath P. Sasi,
Sanggyu Bae,
Jin Song,
Aleksandr Perepletchikov,
Douglas Schneider,
Joseph Carrozza,
Xinhua Yan,
Raj Kishore,
Heiko Enderling,
David A. Goukassian

Published: March 24, 2014
https://doi.org/10.1371/journal.pone.0092373

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