High and Low Doses of Ionizing Radiation Induce Different Secretome Profiles in a Human Skin Model

Qibin Zhang; Melissa Matzke; Athena A. Schepmoes; Ronald J. Moore; Bobbie-Jo Webb-Robertson; Zeping Hu; Matthew E. Monroe; Wei-Jun Qian; Richard D. Smith; William F. Morgan

doi:10.1371/journal.pone.0092332

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Open Access

Peer-reviewed

Research Article

High and Low Doses of Ionizing Radiation Induce Different Secretome Profiles in a Human Skin Model

Qibin Zhang ,

* E-mail: qibin.zhang@pnnl.gov

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Melissa Matzke,

Affiliation Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Athena A. Schepmoes,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Ronald J. Moore,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Bobbie-Jo Webb-Robertson,

Affiliation Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Zeping Hu,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Matthew E. Monroe,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Wei-Jun Qian,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
Richard D. Smith,

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯
William F. Morgan

Affiliation Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington, United States of America
⨯

High and Low Doses of Ionizing Radiation Induce Different Secretome Profiles in a Human Skin Model

Qibin Zhang,
Melissa Matzke,
Athena A. Schepmoes,
Ronald J. Moore,
Bobbie-Jo Webb-Robertson,
Zeping Hu,
Matthew E. Monroe,
Wei-Jun Qian,
Richard D. Smith,
William F. Morgan

Published: March 18, 2014
https://doi.org/10.1371/journal.pone.0092332

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Ionizing radiation
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Extracellular matrix proteins
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Cytoplasm
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Liquid chromatography-mass spectrometry
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Protein folding
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Skin tissue
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Proteomics
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