Human Cancer Cells Retain Modest Levels of Enzymatically Active Matriptase Only in Extracellular Milieu following Induction of Zymogen Activation

• Li-Ling Chu,

  Affiliation Department of Pharmacy, Chi-Mei Medical Center, Tainan, Taiwan

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• Yuan Xu,

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, D.C., United States of America

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• Jie-Ru Yang,

  Affiliation Department of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC

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• Yi-An Hu,

  Affiliation Department of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC

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• Hsiang-Hua Chang,

  Affiliations Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, D.C., United States of America, Department of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC

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• Hong-Yu Lai,

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, D.C., United States of America

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• Chun-Che Tseng,

  Affiliations Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, D.C., United States of America, Department of Biology, Carleton College, Northfield, Minnesota, United States of America

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• Hue-Yu Wang,

  Affiliation Department of Pharmacy, Chi-Mei Medical Center, Tainan, Taiwan

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• Michael D. Johnson,

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, D.C., United States of America

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• Jehng-Kang Wang ,

  * E-mail: lincy@georgetown.edu (C-YL); jkwang@ndmctsgh.edu.tw (J-KW)

  Affiliation Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, ROC

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• Chen-Yong Lin

  * E-mail: lincy@georgetown.edu (C-YL); jkwang@ndmctsgh.edu.tw (J-KW)

  Affiliation Lombardi Comprehensive Cancer Center, Department of Oncology, Georgetown University, Washington, D.C., United States of America

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