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Open Access

Peer-reviewed

Research Article

Embelin Suppresses Growth of Human Pancreatic Cancer Xenografts, and Pancreatic Cancer Cells Isolated from Kras^G12D Mice by Inhibiting Akt and Sonic Hedgehog Pathways

Minzhao Huang,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
⨯
Su-Ni Tang,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
⨯
Ghanshyam Upadhyay,

Affiliation Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
⨯
Justin L. Marsh,

Affiliation Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
⨯
Christopher P. Jackman,

Affiliation Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, Texas, United States of America
⨯
Sharmila Shankar ,

* E-mail: sshankar@kumc.edu (SS); rsrivastava@kumc.edu (RKS)

Affiliation Department of Pathology and Laboratory Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
⨯
Rakesh K. Srivastava

* E-mail: sshankar@kumc.edu (SS); rsrivastava@kumc.edu (RKS)

Affiliation Department of Pharmacology, Toxicology and Therapeutics, and Medicine, The University of Kansas Cancer Center, The University of Kansas Medical Center, Kansas City, Kansas, United States of America
⨯

Embelin Suppresses Growth of Human Pancreatic Cancer Xenografts, and Pancreatic Cancer Cells Isolated from Kras^G12D Mice by Inhibiting Akt and Sonic Hedgehog Pathways

Minzhao Huang,
Su-Ni Tang,
Ghanshyam Upadhyay,
Justin L. Marsh,
Christopher P. Jackman,
Sharmila Shankar,
Rakesh K. Srivastava

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Published: April 2, 2014
https://doi.org/10.1371/journal.pone.0092161

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Pancreatic cancer
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Cancer treatment
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Metastasis
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Mouse models
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Angiogenesis
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Cell proliferation
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Malignant tumors
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