Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells

Raghavendra Pralhada Rao; Luana Scheffer; Sargur M. Srideshikan; Velayoudame Parthibane; Teresa Kosakowska-Cholody; M. Athar Masood; Kunio Nagashima; Prabhakar Gudla; Stephen Lockett; Usha Acharya; Jairaj K. Acharya

doi:10.1371/journal.pone.0092142

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Peer-reviewed

Research Article

Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells

Raghavendra Pralhada Rao,

Affiliation Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Luana Scheffer,

Affiliation Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Sargur M. Srideshikan,

Affiliation Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Velayoudame Parthibane,

Affiliation Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, Maryland, United States of America
⨯
Teresa Kosakowska-Cholody,

Affiliation Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, Maryland, United States of America
⨯
M. Athar Masood,

Affiliation Laboratory of Proteomics and Analytical Technologies, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Kunio Nagashima,

Affiliation Electron Microscopy Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Prabhakar Gudla,

Affiliation Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Stephen Lockett,

Affiliation Optical Microscopy and Analysis Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Usha Acharya,

Affiliation Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Jairaj K. Acharya

* E-mail: acharyaj@mail.nih.gov

Affiliation Laboratory of Cell and Developmental Signaling, National Cancer Institute, Frederick, Maryland, United States of America
⨯

Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells

Raghavendra Pralhada Rao,
Luana Scheffer,
Sargur M. Srideshikan,
Velayoudame Parthibane,
Teresa Kosakowska-Cholody,
M. Athar Masood,
Kunio Nagashima,
Prabhakar Gudla,
Stephen Lockett,
Usha Acharya

Published: March 18, 2014
https://doi.org/10.1371/journal.pone.0092142

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