Mesenchymal Stem Cells from Rats with Chronic Kidney Disease Exhibit Premature Senescence and Loss of Regenerative Potential

Barbara Mara Klinkhammer; Rafael Kramann; Monika Mallau; Anna Makowska; Claudia Renate van Roeyen; Song Rong; Eva Bettina Buecher; Peter Boor; Katarina Kovacova; Stephanie Zok; Bernd Denecke; Esther Stuettgen; Simon Otten; Juergen Floege; Uta Kunter

doi:10.1371/journal.pone.0092115

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Open Access

Peer-reviewed

Research Article

Mesenchymal Stem Cells from Rats with Chronic Kidney Disease Exhibit Premature Senescence and Loss of Regenerative Potential

Barbara Mara Klinkhammer ,

Contributed equally to this work with: Barbara Mara Klinkhammer, Rafael Kramann

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Rafael Kramann ,

Contributed equally to this work with: Barbara Mara Klinkhammer, Rafael Kramann

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Monika Mallau,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Anna Makowska,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Claudia Renate van Roeyen,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Song Rong,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Eva Bettina Buecher,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Peter Boor,

Affiliations Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany, Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany, Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia
⨯
Katarina Kovacova,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Stephanie Zok,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Bernd Denecke,

Affiliation Interdisciplinary Centre for Clinical Research, RWTH Aachen University Hospital, Aachen, Germany
⨯
Esther Stuettgen,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Simon Otten,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Juergen Floege,

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯
Uta Kunter

* E-mail: ukunter@ukaachen.de

Affiliation Division of Nephrology and Immunology, RWTH Aachen University Hospital, Aachen, Germany
⨯

Mesenchymal Stem Cells from Rats with Chronic Kidney Disease Exhibit Premature Senescence and Loss of Regenerative Potential

Barbara Mara Klinkhammer,
Rafael Kramann,
Monika Mallau,
Anna Makowska,
Claudia Renate van Roeyen,
Song Rong,
Eva Bettina Buecher,
Peter Boor,
Katarina Kovacova,
Stephanie Zok

Published: March 25, 2014
https://doi.org/10.1371/journal.pone.0092115

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