Constitutive Activation of Ectodermal β-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure

Xuming Zhu; Sixia Huang; Lingling Zhang; Yumei Wu; Yingwei Chen; Yixin Tao; Yushu Wang; Shigang He; Sanbing Shen; Ji Wu; Baojie Li; Xizhi Guo; Lin He; Gang Ma

doi:10.1371/journal.pone.0092092

Loading metrics

Open Access

Peer-reviewed

Research Article

Constitutive Activation of Ectodermal β-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure

Xuming Zhu,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Sixia Huang,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Lingling Zhang,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Yumei Wu,

Affiliation Department of Dermatology, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
⨯
Yingwei Chen,

Affiliation Department of Dermatology, Luwan Branch, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
⨯
Yixin Tao,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Yushu Wang,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Shigang He,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China, Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, PR China
⨯
Sanbing Shen,

Affiliations Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China, Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, Newcastle Road, Galway, Ireland
⨯
Ji Wu,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Baojie Li,

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Xizhi Guo ,

* E-mail: xzguo2005@gmail.com (XG); helinhelin3@gmail.com (LH); magang2004@gmail.com (GM)

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Lin He ,

* E-mail: xzguo2005@gmail.com (XG); helinhelin3@gmail.com (LH); magang2004@gmail.com (GM)

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯
Gang Ma

* E-mail: xzguo2005@gmail.com (XG); helinhelin3@gmail.com (LH); magang2004@gmail.com (GM)

Affiliation Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, PR China
⨯

Constitutive Activation of Ectodermal β-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure

Xuming Zhu,
Sixia Huang,
Lingling Zhang,
Yumei Wu,
Yingwei Chen,
Yixin Tao,
Yushu Wang,
Shigang He,
Sanbing Shen,
Ji Wu

Published: March 19, 2014
https://doi.org/10.1371/journal.pone.0092092

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Ectoderm
Is the Subject Area "Ectoderm" applicable to this article?

Thanks for your feedback.
Body limbs
Is the Subject Area "Body limbs" applicable to this article?

Thanks for your feedback.
Limb buds
Is the Subject Area "Limb buds" applicable to this article?

Thanks for your feedback.
Abdomen
Is the Subject Area "Abdomen" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Alizarin staining
Is the Subject Area "Alizarin staining" applicable to this article?

Thanks for your feedback.
Hematoxylin staining
Is the Subject Area "Hematoxylin staining" applicable to this article?

Thanks for your feedback.
Mesoderm
Is the Subject Area "Mesoderm" applicable to this article?

Thanks for your feedback.