EGF-Like-Domain-7 Is Required for VEGF-Induced Akt/ERK Activation and Vascular Tube Formation in an Ex Vivo Angiogenesis Assay

Kimio Takeuchi; Ryoji Yanai; Fumiaki Kumase; Yuki Morizane; Jun Suzuki; Maki Kayama; Katarzyna Brodowska; Mitsuru Nakazawa; Joan W. Miller; Kip M. Connor; Demetrios G. Vavvas

doi:10.1371/journal.pone.0091849

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Peer-reviewed

Research Article

EGF-Like-Domain-7 Is Required for VEGF-Induced Akt/ERK Activation and Vascular Tube Formation in an Ex Vivo Angiogenesis Assay

Kimio Takeuchi,

Affiliations The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Aomori, Japan
⨯
Ryoji Yanai,

Affiliation The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Fumiaki Kumase,

Affiliations The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yuki Morizane,

Affiliations The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Jun Suzuki,

Affiliation The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Maki Kayama,

Affiliation The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
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Katarzyna Brodowska,

Affiliation The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Mitsuru Nakazawa,

Affiliation Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Aomori, Japan
⨯
Joan W. Miller,

Affiliation The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kip M. Connor,

Affiliation The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
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Demetrios G. Vavvas

* E-mail: vavvas@meei.harvard.edu

Affiliation The Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

EGF-Like-Domain-7 Is Required for VEGF-Induced Akt/ERK Activation and Vascular Tube Formation in an Ex Vivo Angiogenesis Assay

Kimio Takeuchi,
Ryoji Yanai,
Fumiaki Kumase,
Yuki Morizane,
Jun Suzuki,
Maki Kayama,
Katarzyna Brodowska,
Mitsuru Nakazawa,
Joan W. Miller,
Kip M. Connor

Published: March 19, 2014
https://doi.org/10.1371/journal.pone.0091849

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