Deregulation of Mitochondria-Shaping Proteins Opa-1 and Drp-1 in Manganese-Induced Apoptosis

Agustina Alaimo; Roxana M. Gorojod; Juan Beauquis; Manuel J. Muñoz; Flavia Saravia; Mónica L. Kotler

doi:10.1371/journal.pone.0091848

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Peer-reviewed

Research Article

Deregulation of Mitochondria-Shaping Proteins Opa-1 and Drp-1 in Manganese-Induced Apoptosis

Agustina Alaimo,

Affiliation Laboratorio de Apoptosis en el Sistema Nervioso y Nano-Oncología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Química Biológica, Ciencias Exactas y Naturales (IQUIBICEN-CONICET), Buenos Aires, Argentina
⨯
Roxana M. Gorojod,

Affiliation Laboratorio de Apoptosis en el Sistema Nervioso y Nano-Oncología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Química Biológica, Ciencias Exactas y Naturales (IQUIBICEN-CONICET), Buenos Aires, Argentina
⨯
Juan Beauquis,

Affiliation Laboratorio de Neurobiología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
⨯
Manuel J. Muñoz,

Affiliation Departamento de Fisiología, Biología Molecular y Celular and Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
⨯
Flavia Saravia,

Affiliation Laboratorio de Neurobiología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Biología y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina
⨯
Mónica L. Kotler

* E-mail: moniquekotler@gmail.com

Affiliation Laboratorio de Apoptosis en el Sistema Nervioso y Nano-Oncología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and Instituto de Química Biológica, Ciencias Exactas y Naturales (IQUIBICEN-CONICET), Buenos Aires, Argentina
⨯

Deregulation of Mitochondria-Shaping Proteins Opa-1 and Drp-1 in Manganese-Induced Apoptosis

Agustina Alaimo,
Roxana M. Gorojod,
Juan Beauquis,
Manuel J. Muñoz,
Flavia Saravia,
Mónica L. Kotler

Published: March 14, 2014
https://doi.org/10.1371/journal.pone.0091848

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Mitochondria
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Apoptosis
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Transfection
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Neostriatum
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Manganese
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Small interfering RNA
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