BEX1 Promotes Imatinib-Induced Apoptosis by Binding to and Antagonizing BCL-2

Qian Xiao; Yeting Hu; Yue Liu; Zhanhuai Wang; Haitao Geng; Lifeng Hu; Dengyong Xu; Ke Wang; Lei Zheng; Shu Zheng; Kefeng Ding

doi:10.1371/journal.pone.0091782

Loading metrics

Open Access

Peer-reviewed

Research Article

BEX1 Promotes Imatinib-Induced Apoptosis by Binding to and Antagonizing BCL-2

Qian Xiao,

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Yeting Hu,

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Yue Liu,

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Zhanhuai Wang,

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Haitao Geng,

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Lifeng Hu,

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Dengyong Xu,

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Ke Wang,

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Lei Zheng ,

* E-mail: Dingkefeng@zju.edu.cn (KD); zhengshu@zju.edu.cn (SZ); lzheng6@jhmi.edu (LZ)

Affiliations The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China, Department of Oncology and Department of Surgery, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Shu Zheng ,

* E-mail: Dingkefeng@zju.edu.cn (KD); zhengshu@zju.edu.cn (SZ); lzheng6@jhmi.edu (LZ)

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯
Kefeng Ding

* E-mail: Dingkefeng@zju.edu.cn (KD); zhengshu@zju.edu.cn (SZ); lzheng6@jhmi.edu (LZ)

Affiliations The Key Laboratory of Cancer Prevention and Intervention of China National Ministry of Education, The Key Laboratory of Molecular Biology in Medical Sciences of Zhejiang Province, Cancer Institute, Hangzhou, Zhejiang, China, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
⨯

BEX1 Promotes Imatinib-Induced Apoptosis by Binding to and Antagonizing BCL-2

Qian Xiao,
Yeting Hu,
Yue Liu,
Zhanhuai Wang,
Haitao Geng,
Lifeng Hu,
Dengyong Xu,
Ke Wang,
Lei Zheng,
Shu Zheng

Published: March 13, 2014
https://doi.org/10.1371/journal.pone.0091782

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Mitochondria
Is the Subject Area "Mitochondria" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Co-immunoprecipitation
Is the Subject Area "Co-immunoprecipitation" applicable to this article?

Thanks for your feedback.
Drug interactions
Is the Subject Area "Drug interactions" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Yeast
Is the Subject Area "Yeast" applicable to this article?

Thanks for your feedback.
Two-hybrid screening
Is the Subject Area "Two-hybrid screening" applicable to this article?

Thanks for your feedback.