Assessment of Treatment Response by Total Tumor Volume and Global Apparent Diffusion Coefficient Using Diffusion-Weighted MRI in Patients with Metastatic Bone Disease: A Feasibility Study

Matthew D. Blackledge; David J. Collins; Nina Tunariu; Matthew R. Orton; Anwar R. Padhani; Martin O. Leach; Dow-Mu Koh

doi:10.1371/journal.pone.0091779

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Open Access

Peer-reviewed

Research Article

Assessment of Treatment Response by Total Tumor Volume and Global Apparent Diffusion Coefficient Using Diffusion-Weighted MRI in Patients with Metastatic Bone Disease: A Feasibility Study

Matthew D. Blackledge,

Affiliation Radiotherapy and Imaging Division, Cancer Research UK and Engineering and Physical Sciences Research Council Cancer Imaging Centre at The Institute of Cancer Research and The Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
⨯
David J. Collins,

Affiliation Radiotherapy and Imaging Division, Cancer Research UK and Engineering and Physical Sciences Research Council Cancer Imaging Centre at The Institute of Cancer Research and The Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
⨯
Nina Tunariu,

Affiliation Radiotherapy and Imaging Division, Cancer Research UK and Engineering and Physical Sciences Research Council Cancer Imaging Centre at The Institute of Cancer Research and The Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
⨯
Matthew R. Orton,

Affiliation Radiotherapy and Imaging Division, Cancer Research UK and Engineering and Physical Sciences Research Council Cancer Imaging Centre at The Institute of Cancer Research and The Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
⨯
Anwar R. Padhani,

Affiliation Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood, Middlesex, United Kingdom
⨯
Martin O. Leach ,

* E-mail: Martin.Leach@icr.ac.uk

Affiliation Radiotherapy and Imaging Division, Cancer Research UK and Engineering and Physical Sciences Research Council Cancer Imaging Centre at The Institute of Cancer Research and The Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
⨯
Dow-Mu Koh

Affiliation Radiotherapy and Imaging Division, Cancer Research UK and Engineering and Physical Sciences Research Council Cancer Imaging Centre at The Institute of Cancer Research and The Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom
⨯

Assessment of Treatment Response by Total Tumor Volume and Global Apparent Diffusion Coefficient Using Diffusion-Weighted MRI in Patients with Metastatic Bone Disease: A Feasibility Study

Matthew D. Blackledge,
David J. Collins,
Nina Tunariu,
Matthew R. Orton,
Anwar R. Padhani,
Martin O. Leach,
Dow-Mu Koh

Published: April 7, 2014
https://doi.org/10.1371/journal.pone.0091779

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