Trichostatin A Targets the Mitochondrial Respiratory Chain, Increasing Mitochondrial Reactive Oxygen Species Production to Trigger Apoptosis in Human Breast Cancer Cells

Shujuan Sun; Yingyan Han; Jia Liu; Yong Fang; Yuan Tian; Jianfeng Zhou; Ding Ma; Peng Wu

doi:10.1371/journal.pone.0091610

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Peer-reviewed

Research Article

Trichostatin A Targets the Mitochondrial Respiratory Chain, Increasing Mitochondrial Reactive Oxygen Species Production to Trigger Apoptosis in Human Breast Cancer Cells

Shujuan Sun ,

Contributed equally to this work with: Shujuan Sun, Yingyan Han

Affiliation Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Yingyan Han ,

Contributed equally to this work with: Shujuan Sun, Yingyan Han

Affiliation Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Jia Liu,

Affiliation Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Yong Fang,

Affiliation Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Yuan Tian,

Affiliation Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Jianfeng Zhou,

Affiliation Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Ding Ma ,

* E-mail: dma@tjh.tjmu.edu.cn (DM); pengwu8626@126.com (PW)

Affiliation Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Peng Wu

* E-mail: dma@tjh.tjmu.edu.cn (DM); pengwu8626@126.com (PW)

Affiliation Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯

Trichostatin A Targets the Mitochondrial Respiratory Chain, Increasing Mitochondrial Reactive Oxygen Species Production to Trigger Apoptosis in Human Breast Cancer Cells

Shujuan Sun,
Yingyan Han,
Jia Liu,
Yong Fang,
Yuan Tian,
Jianfeng Zhou,
Ding Ma,
Peng Wu

Published: March 13, 2014
https://doi.org/10.1371/journal.pone.0091610

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Mitochondria
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Breast cancer
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Reactive oxygen species
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