Evidence of a Novel Mechanism for Partial γ-Secretase Inhibition Induced Paradoxical Increase in Secreted Amyloid β Protein

• Eliza Barnwell ,

  Contributed equally to this work with: Eliza Barnwell, Vasudevaraju Padmaraju

  Affiliation Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Vasudevaraju Padmaraju ,

  Contributed equally to this work with: Eliza Barnwell, Vasudevaraju Padmaraju

  Affiliation Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Robert Baranello ,

  ¶These authors also contributed equally to this work.

  Affiliation Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Javier Pacheco-Quinto,

  Affiliation Biomedical Research Institute of New Jersey, MidAtlantic Neonatology Associates and Atlantic Health System, Morristown, New Jersey, United States of America

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• Craig Crosson,

  Affiliation Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Zsolt Ablonczy,

  Affiliation Department of Ophthalmology, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Elizabeth Eckman,

  Affiliation Biomedical Research Institute of New Jersey, MidAtlantic Neonatology Associates and Atlantic Health System, Morristown, New Jersey, United States of America

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• Christopher B. Eckman,

  Affiliation Biomedical Research Institute of New Jersey, MidAtlantic Neonatology Associates and Atlantic Health System, Morristown, New Jersey, United States of America

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• Viswanathan Ramakrishnan,

  Affiliation Department of Biostatistics, Medical University of South Carolina, Charleston, South Carolina, United States of America

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• Nigel H. Greig,

  Affiliation Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, United States of America

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• Miguel A. Pappolla ,

  ¶These authors also contributed equally to this work.

  Affiliation Department of Neurology, University of Texas Medical Branch, Galveston, Texas, United States of America

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• Kumar Sambamurti

  * E-mail: sambak@musc.edu

  Affiliation Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, United States of America

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