7,8-Dihydroxyflavone, a Small Molecule TrkB Agonist, Improves Spatial Memory and Increases Thin Spine Density in a Mouse Model of Alzheimer Disease-Like Neuronal Loss

• Nicholas A. Castello,

  Affiliations Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America, Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America

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• Michael H. Nguyen,

  Affiliations Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America, Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America

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• Jenny D. Tran,

  Affiliations Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America, Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America

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• David Cheng,

  Affiliations Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America, Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America

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• Kim N. Green,

  Affiliations Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America, Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America

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• Frank M. LaFerla

  * E-mail: laferla@uci.edu

  Affiliations Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America, Department of Neurobiology and Behavior, University of California Irvine, Irvine, California, United States of America

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