Acute Ethanol Causes Hepatic Mitochondrial Depolarization in Mice: Role of Ethanol Metabolism

Zhi Zhong; Venkat K. Ramshesh; Hasibur Rehman; Qinlong Liu; Tom P. Theruvath; Yasodha Krishnasamy; John J. Lemasters

doi:10.1371/journal.pone.0091308

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Open Access

Peer-reviewed

Research Article

Acute Ethanol Causes Hepatic Mitochondrial Depolarization in Mice: Role of Ethanol Metabolism

Zhi Zhong ,

* E-mail: zhong@musc.edu

Affiliations Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Venkat K. Ramshesh,

Affiliations Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
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Hasibur Rehman,

Current address: Department of Biology, Faculty of Sciences, University of Tabuk, Tabuk, Saudi Arabia

Affiliation Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Qinlong Liu,

Affiliation Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Tom P. Theruvath,

Affiliation Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
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Yasodha Krishnasamy,

Affiliation Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
John J. Lemasters

Affiliations Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina, United States of America, Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯

Acute Ethanol Causes Hepatic Mitochondrial Depolarization in Mice: Role of Ethanol Metabolism

Zhi Zhong,
Venkat K. Ramshesh,
Hasibur Rehman,
Qinlong Liu,
Tom P. Theruvath,
Yasodha Krishnasamy,
John J. Lemasters

Published: March 11, 2014
https://doi.org/10.1371/journal.pone.0091308

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Mitochondria
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Ethanol
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Depolarization
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Hepatocytes
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Acetaldehyde
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Fatty liver
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Steatosis
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Oxidation
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