Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

Agnes L. Nishimura; Carole Shum; Emma L. Scotter; Amr Abdelgany; Valentina Sardone; Jamie Wright; Youn-Bok Lee; Han-Jou Chen; Bilada Bilican; Monica Carrasco; Tom Maniatis; Siddharthan Chandran; Boris Rogelj; Jean-Marc Gallo; Christopher E. Shaw

doi:10.1371/journal.pone.0091269

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Peer-reviewed

Research Article

Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

Agnes L. Nishimura,

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯
Carole Shum,

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯
Emma L. Scotter,

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯
Amr Abdelgany,

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯
Valentina Sardone,

Affiliation Department of Public Health, Neuroscience, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy
⨯
Jamie Wright,

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯
Youn-Bok Lee,

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯
Han-Jou Chen,

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯
Bilada Bilican,

Affiliation MRC Centre for Regenerative Medicine and Centre for Neurodegeneration, University of Edinburgh, Edinburgh, United Kingdom
⨯
Monica Carrasco,

Affiliation Department of Biochemistry & Molecular Biophysics, Columbia University, New York, New York, United States of America
⨯
Tom Maniatis,

Affiliation Department of Biochemistry & Molecular Biophysics, Columbia University, New York, New York, United States of America
⨯
Siddharthan Chandran,

Affiliation MRC Centre for Regenerative Medicine and Centre for Neurodegeneration, University of Edinburgh, Edinburgh, United Kingdom
⨯
Boris Rogelj,

Affiliation Department of Biotechnology, Jozef Stefan Institute, Ljubljana, Slovenia
⨯
Jean-Marc Gallo,

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯
Christopher E. Shaw

* E-mail: Christopher.Shaw@kcl.ac.uk

Affiliation Department of Clinical Neuroscience, King's College London, London, United Kingdom
⨯

Allele-Specific Knockdown of ALS-Associated Mutant TDP-43 in Neural Stem Cells Derived from Induced Pluripotent Stem Cells

Agnes L. Nishimura,
Carole Shum,
Emma L. Scotter,
Amr Abdelgany,
Valentina Sardone,
Jamie Wright,
Youn-Bok Lee,
Han-Jou Chen,
Bilada Bilican,
Monica Carrasco

Published: March 20, 2014
https://doi.org/10.1371/journal.pone.0091269

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