High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27Kip1 Transcriptional Inhibitor

Brandon J. Walters; Wenwei Lin; Shiyong Diao; Mark Brimble; Luigi I. Iconaru; Jennifer Dearman; Asli Goktug; Taosheng Chen; Jian Zuo

doi:10.1371/journal.pone.0091173

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Peer-reviewed

Research Article

High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27^Kip1 Transcriptional Inhibitor

Brandon J. Walters,

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Wenwei Lin,

Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Shiyong Diao,

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Mark Brimble,

Affiliations Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America, University of Bath, Bath, United Kingdom
⨯
Luigi I. Iconaru,

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Jennifer Dearman,

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Asli Goktug,

Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Taosheng Chen,

Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Jian Zuo

* E-mail: jian.zuo@stjude.org

Affiliation Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯

High-Throughput Screening Reveals Alsterpaullone, 2-Cyanoethyl as a Potent p27^Kip1 Transcriptional Inhibitor

Brandon J. Walters,
Wenwei Lin,
Shiyong Diao,
Mark Brimble,
Luigi I. Iconaru,
Jennifer Dearman,
Asli Goktug,
Taosheng Chen,
Jian Zuo

Published: March 19, 2014
https://doi.org/10.1371/journal.pone.0091173

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