Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old

Laura Wiley; Deepthi Ashok; Carmen Martin-Ruiz; Duncan C. S. Talbot; Joanna Collerton; Andrew Kingston; Karen Davies; Patrick F. Chinnery; Michael Catt; Carol Jagger; Thomas B. L. Kirkwood; Thomas von Zglinicki

doi:10.1371/journal.pone.0091005

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Peer-reviewed

Research Article

Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old

Laura Wiley,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Deepthi Ashok,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Carmen Martin-Ruiz,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Duncan C. S. Talbot,

Affiliation Unilever Discover, Colworth Science Park, Sharnbrook, Bedfordshire, United Kingdom
⨯
Joanna Collerton,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Andrew Kingston,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Karen Davies,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Patrick F. Chinnery,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Michael Catt,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Carol Jagger,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Thomas B. L. Kirkwood,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Thomas von Zglinicki

* E-mail: t.vonzglinicki@newcastle.ac.uk

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯

Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old

Laura Wiley,
Deepthi Ashok,
Carmen Martin-Ruiz,
Duncan C. S. Talbot,
Joanna Collerton,
Andrew Kingston,
Karen Davies,
Patrick F. Chinnery,
Michael Catt,
Carol Jagger

Published: March 10, 2014
https://doi.org/10.1371/journal.pone.0091005

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