A Novel Blood-Brain Barrier Co-Culture System for Drug Targeting of Alzheimer’s Disease: Establishment by Using Acitretin as a Model Drug

Open Access

Peer-reviewed

Research Article

Christian Freese ,

Contributed equally to this work with: Christian Freese, Sven Reinhardt

* E-mail: freesec@uni-mainz.de

Affiliation REPAIR-lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany
⨯
Sven Reinhardt ,

Contributed equally to this work with: Christian Freese, Sven Reinhardt

Affiliation Department of Psychiatry and Psychotherapy, Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
⨯
Gudrun Hefner,

Affiliation Department of Psychiatry and Psychotherapy, Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
⨯
Ronald E. Unger,

Affiliation REPAIR-lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany
⨯
C. James Kirkpatrick,

Affiliation REPAIR-lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz and European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Mainz, Germany
⨯
Kristina Endres

Affiliation Department of Psychiatry and Psychotherapy, Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany
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Endothelial cells
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Blood-brain barrier
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Tight junctions
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Permeability
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Alzheimer's disease
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Cytotoxicity assay
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