Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis in Sepsis

Matthew C. Exline; Steven Justiniano; Jennifer L. Hollyfield; Freweine Berhe; Beth Y. Besecker; Srabani Das; Mark D. Wewers; Anasuya Sarkar

doi:10.1371/journal.pone.0090968

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Open Access

Peer-reviewed

Research Article

Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis in Sepsis

Matthew C. Exline,

Affiliation Davis Heart and Lung Research Institute, Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Steven Justiniano,

Affiliation Davis Heart and Lung Research Institute, Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Jennifer L. Hollyfield,

Affiliation Davis Heart and Lung Research Institute, Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Freweine Berhe,

Affiliation Davis Heart and Lung Research Institute, Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Beth Y. Besecker,

Affiliation Davis Heart and Lung Research Institute, Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Srabani Das,

Affiliation Davis Heart and Lung Research Institute, Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Mark D. Wewers,

Affiliation Davis Heart and Lung Research Institute, Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯
Anasuya Sarkar

* E-mail: anasuya.sarkar@osumc.edu

Affiliation Davis Heart and Lung Research Institute, Pulmonary, Allergy, Critical Care and Sleep Medicine Division, Wexner Medical Center, The Ohio State University, Columbus, Ohio, United States of America
⨯

Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis in Sepsis

Matthew C. Exline,
Steven Justiniano,
Jennifer L. Hollyfield,
Freweine Berhe,
Beth Y. Besecker,
Srabani Das,
Mark D. Wewers,
Anasuya Sarkar

Published: March 18, 2014
https://doi.org/10.1371/journal.pone.0090968

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Apoptosis
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Lymphocytes
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Sepsis
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Blood
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Blood plasma
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Inflammasomes
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Cell death
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