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Open Access

Peer-reviewed

Research Article

Selective Inhibition of PI3K/Akt/mTOR Signaling Pathway Regulates Autophagy of Macrophage and Vulnerability of Atherosclerotic Plaque

Chungang Zhai,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Jing Cheng,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Haroon Mujahid,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Hefeng Wang,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Jing Kong,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Yue Yin,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Jifu Li,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Yun Zhang,

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Xiaoping Ji ,

* E-mail: chenwenqiang33@sina.com (WC); jxp64@163.com (XJ)

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯
Wenqiang Chen

* E-mail: chenwenqiang33@sina.com (WC); jxp64@163.com (XJ)

Affiliation The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China
⨯

Selective Inhibition of PI3K/Akt/mTOR Signaling Pathway Regulates Autophagy of Macrophage and Vulnerability of Atherosclerotic Plaque

Chungang Zhai,
Jing Cheng,
Haroon Mujahid,
Hefeng Wang,
Jing Kong,
Yue Yin,
Jifu Li,
Yun Zhang,
Xiaoping Ji,
Wenqiang Chen

x

Published: March 5, 2014
https://doi.org/10.1371/journal.pone.0090563

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Autophagic cell death
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Macrophages
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Atherosclerosis
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Rabbits
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Signal inhibition
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Monoclonal antibodies
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Aorta
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Inflammation
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