Hypoxia Promotes Migration and Induces CXCR4 Expression via HIF-1α Activation in Human Osteosarcoma

Mingjun Guo; Chengkui Cai; Guangyi Zhao; Xiuchun Qiu; Haien Zhao; Qiong Ma; Liying Tian; Xuelian Li; Yunsheng Hu; Bo Liao; Baoan Ma; Qingyu Fan

doi:10.1371/journal.pone.0090518

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Peer-reviewed

Research Article

Hypoxia Promotes Migration and Induces CXCR4 Expression via HIF-1α Activation in Human Osteosarcoma

Mingjun Guo ,

Contributed equally to this work with: Mingjun Guo, Chengkui Cai, Guangyi Zhao

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Chengkui Cai ,

Contributed equally to this work with: Mingjun Guo, Chengkui Cai, Guangyi Zhao

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Guangyi Zhao ,

Contributed equally to this work with: Mingjun Guo, Chengkui Cai, Guangyi Zhao

Affiliation Department of Orthopaedics, Bethune International Peace Hospital, Shijiazhuang, Hebei, People's Republic of China
⨯
Xiuchun Qiu,

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Haien Zhao,

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Qiong Ma,

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Liying Tian,

Affiliation Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Xuelian Li,

Affiliation Department of Surgery, Xi'an Hospital of TCM, Shaanxi, People's Republic of China
⨯
Yunsheng Hu,

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Bo Liao,

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Baoan Ma ,

* E-mail: gukemba@fmmu.edu.cn (BM); bonetm@fmmu.edu.cn (QF)

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯
Qingyu Fan

* E-mail: gukemba@fmmu.edu.cn (BM); bonetm@fmmu.edu.cn (QF)

Affiliation Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
⨯

Hypoxia Promotes Migration and Induces CXCR4 Expression via HIF-1α Activation in Human Osteosarcoma

Mingjun Guo,
Chengkui Cai,
Guangyi Zhao,
Xiuchun Qiu,
Haien Zhao,
Qiong Ma,
Liying Tian,
Xuelian Li,
Yunsheng Hu,
Bo Liao

Published: March 11, 2014
https://doi.org/10.1371/journal.pone.0090518

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Hypoxia
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Metastasis
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