Heterologous Expression of the Thiopeptide Antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor Requires Deletion of Ribosomal Genes from the Expression Construct

Open Access

Peer-reviewed

Research Article

Katrin Flinspach,

Affiliations Pharmaceutical Institute, University of Tübingen, Tübingen, Germany, German Centre for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany
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Claudia Kapitzke,

Affiliation Pharmaceutical Institute, University of Tübingen, Tübingen, Germany
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Arianna Tocchetti,

Affiliation KtedoGen Srl, Milan, Italy
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Margherita Sosio,

Affiliations KtedoGen Srl, Milan, Italy, NAICONS Srl, Milan, Italy
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Alexander K. Apel

* E-mail: kristian.apel@uni-tuebingen.de

Affiliations Pharmaceutical Institute, University of Tübingen, Tübingen, Germany, German Centre for Infection Research (DZIF), partner site Tübingen, Tübingen, Germany
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Streptomyces
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Antibiotics
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Gene regulation
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Transcriptional control
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Biosynthesis
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Regulator genes
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Liquid chromatography-mass spectrometry
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Ribosomal RNA
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