Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34+ Stem Cells-Reconstituted NOD-scid IL2rγnull Mice

Open Access

Peer-reviewed

Research Article

Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34⁺ Stem Cells-Reconstituted NOD-scid IL2rγ^null Mice

Fang Xiao,

Affiliation Medical Research Council (MRC) for Transplantation, King's College London, London, United Kingdom
⨯
Liang Ma,

Current address: Heart Centre, William Harvey Research Institute, Queen Mary, University of London, London, United Kingdom

Affiliation Medical Research Council (MRC) for Transplantation, King's College London, London, United Kingdom
⨯
Min Zhao,

Affiliation Department of Diabetes & Endocrinology, King's College London, London, United Kingdom
⨯
Guocai Huang,

Affiliation Department of Diabetes & Endocrinology, King's College London, London, United Kingdom
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Vincenzo Mirenda,

Affiliation Medical Research Council (MRC) for Transplantation, King's College London, London, United Kingdom
⨯
Anthony Dorling,

Affiliation Medical Research Council (MRC) for Transplantation, King's College London, London, United Kingdom
⨯
Robert Lechler ,

Contributed equally to this work with: Robert Lechler, Giovanna Lombardi

Affiliation Medical Research Council (MRC) for Transplantation, King's College London, London, United Kingdom
⨯
Giovanna Lombardi

Contributed equally to this work with: Robert Lechler, Giovanna Lombardi

* E-mail: giovanna.lombardi@kcl.ac.uk

Affiliation Medical Research Council (MRC) for Transplantation, King's College London, London, United Kingdom
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Regulatory T cells
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Mouse models
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T cells
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Islet transplantation
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Immune response
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Transplant rejection
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Blood sugar
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Spleen
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