p62/SQSTM1 Accumulation in Squamous Cell Carcinoma of Head and Neck Predicts Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitors

Wen-Liang Kuo; Marina N. Sharifi; Mark W. Lingen; Omar Ahmed; Jing Liu; Madhavi Nagilla; Kay F. Macleod; Ezra E. W. Cohen

doi:10.1371/journal.pone.0090171

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Peer-reviewed

Research Article

p62/SQSTM1 Accumulation in Squamous Cell Carcinoma of Head and Neck Predicts Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitors

Wen-Liang Kuo,

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Marina N. Sharifi,

Affiliations Committee on Cancer Biology, University of Chicago, Chicago, Illinois, United States of America, Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, United States of America
⨯
Mark W. Lingen,

Affiliations Committee on Cancer Biology, University of Chicago, Chicago, Illinois, United States of America, Department of Pathology, University of Chicago, Chicago, Illinois, United States of America, Comprehensive Cancer Center; University of Chicago, Chicago, Illinois, United States of America
⨯
Omar Ahmed,

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Jing Liu,

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Madhavi Nagilla,

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Kay F. Macleod,

Affiliations Committee on Cancer Biology, University of Chicago, Chicago, Illinois, United States of America, Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois, United States of America, Comprehensive Cancer Center; University of Chicago, Chicago, Illinois, United States of America
⨯
Ezra E. W. Cohen

* E-mail: ecohen@.ucsd.edu

Current address: Moores Cancer Center, The University of California San Diego, La Jolla, California, United States of America

Affiliations Department of Medicine, University of Chicago, Chicago, Illinois, United States of America, Committee on Cancer Biology, University of Chicago, Chicago, Illinois, United States of America, Comprehensive Cancer Center; University of Chicago, Chicago, Illinois, United States of America
⨯

p62/SQSTM1 Accumulation in Squamous Cell Carcinoma of Head and Neck Predicts Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitors

Wen-Liang Kuo,
Marina N. Sharifi,
Mark W. Lingen,
Omar Ahmed,
Jing Liu,
Madhavi Nagilla,
Kay F. Macleod,
Ezra E. W. Cohen

Published: March 5, 2014
https://doi.org/10.1371/journal.pone.0090171

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Breast cancer
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Head and neck cancers
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Protein expression
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DNA methylation
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