Pharmacological Inhibition of Cochlear Mitochondrial Respiratory Chain Induces Secondary Inflammation in the Lateral Wall: A Potential Therapeutic Target for Sensorineural Hearing Loss

• Masato Fujioka,

  Affiliations Department of Otolaryngology, Head and Neck Surgery, Keio University, School of Medicine, Shinjuku, Tokyo, Japan, Department of Physiology, School of Medicine, Keio University, School of Medicine, Shinjuku, Tokyo, Japan

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• Yasuhide Okamoto,

  Affiliations Department of Otorhinolaryngology, Inagi Municipal Hospital, Inagi, Tokyo, Japan, The Laboratory of Auditory Disorders and Division of Hearing and Balance Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan

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• Seiichi Shinden,

  Affiliations Department of Otolaryngology, Saiseikai Utsunomiya Hospital, Utsunomiya, Tochigi, Japan, The Laboratory of Auditory Disorders and Division of Hearing and Balance Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan

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• Hirotaka James Okano,

  Affiliations Department of Physiology, School of Medicine, Keio University, School of Medicine, Shinjuku, Tokyo, Japan, Division of Regenerative Medicine, Jikei University School of Medicine, Tokyo, Japan

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• Hideyuki Okano,

  Affiliation Department of Physiology, School of Medicine, Keio University, School of Medicine, Shinjuku, Tokyo, Japan

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• Kaoru Ogawa,

  Affiliation Department of Otolaryngology, Head and Neck Surgery, Keio University, School of Medicine, Shinjuku, Tokyo, Japan

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• Tatsuo Matsunaga

  * E-mail: matsunagatatsuo@kankakuki.go.jp

  Affiliation The Laboratory of Auditory Disorders and Division of Hearing and Balance Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo, Japan

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