RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage

Chantal H. M. A. Ramaekers; Twan van den Beucken; Robert G. Bristow; Roland K. Chiu; Daniel Durocher; Bradly G. Wouters

doi:10.1371/journal.pone.0089997

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Peer-reviewed

Research Article

RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage

Chantal H. M. A. Ramaekers ,

Contributed equally to this work with: Chantal H. M. A. Ramaekers, Twan van den Beucken

Affiliations Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Maastricht Radiation Oncology (MaastRO) Lab, GROW – School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
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Twan van den Beucken ,

Contributed equally to this work with: Chantal H. M. A. Ramaekers, Twan van den Beucken

Affiliations Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Maastricht Radiation Oncology (MaastRO) Lab, GROW – School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
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Robert G. Bristow,

Affiliations Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
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Roland K. Chiu,

Affiliation Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Daniel Durocher,

Affiliations Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
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Bradly G. Wouters

* E-mail: bwouters@uhnresearch.ca

Affiliations Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Maastricht Radiation Oncology (MaastRO) Lab, GROW – School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands, Departments of Radiation Oncology and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
⨯

RNF8-Independent Lys63 Poly-Ubiquitylation Prevents Genomic Instability in Response to Replication-Associated DNA Damage

Chantal H. M. A. Ramaekers,
Twan van den Beucken,
Robert G. Bristow,
Roland K. Chiu,
Daniel Durocher,
Bradly G. Wouters

Published: February 28, 2014
https://doi.org/10.1371/journal.pone.0089997

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DNA repair
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DNA replication
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Synthesis phase
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Chromosomal deletions
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DNA damage
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Point mutation
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Non-homologous end joining
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