The Prevalence and Molecular Spectrum of α- and β-Globin Gene Mutations in 14,332 Families of Guangdong Province, China

Aihua Yin; Bing Li; Mingyong Luo; Longchang Xu; Li Wu; Liang Zhang; Yuanzhu Ma; Tingting Chen; Shuang Gao; Juqing Liang; Hao Guo; Danqing Qin; Jicheng Wang; Tenglong Yuan; Yixia Wang; Wei-wei Huang; Wen-Fei He; Yanxia Zhang; Chang Liu; Sujian Xia; Qingshan Chen; Qingguo Zhao; Xiaozhuang Zhang

doi:10.1371/journal.pone.0089855

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Open Access

Peer-reviewed

Research Article

The Prevalence and Molecular Spectrum of α- and β-Globin Gene Mutations in 14,332 Families of Guangdong Province, China

Aihua Yin ,

Contributed equally to this work with: Aihua Yin, Bing Li, Mingyong Luo

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Bing Li ,

Contributed equally to this work with: Aihua Yin, Bing Li, Mingyong Luo

Affiliations Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Department of Healthcare, Guangdong Women And Children Hospital, Guangzhou, Guangdong, China
⨯
Mingyong Luo ,

Contributed equally to this work with: Aihua Yin, Bing Li, Mingyong Luo

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Longchang Xu,

Affiliations Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Department of Healthcare, Guangdong Women And Children Hospital, Guangzhou, Guangdong, China
⨯
Li Wu,

Affiliations Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Department of Healthcare, Guangdong Women And Children Hospital, Guangzhou, Guangdong, China
⨯
Liang Zhang,

Affiliation BioChain (Beijing) Science and Technology Inc., Beijing, China
⨯
Yuanzhu Ma,

Affiliations Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Department of Healthcare, Guangdong Women And Children Hospital, Guangzhou, Guangdong, China
⨯
Tingting Chen,

Affiliations Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Department of Healthcare, Guangdong Women And Children Hospital, Guangzhou, Guangdong, China
⨯
Shuang Gao,

Affiliations Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Department of Healthcare, Guangdong Women And Children Hospital, Guangzhou, Guangdong, China
⨯
Juqing Liang,

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Hao Guo,

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Danqing Qin,

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Jicheng Wang,

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Tenglong Yuan,

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Yixia Wang,

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Wei-wei Huang,

Affiliation BioChain (Beijing) Science and Technology Inc., Beijing, China
⨯
Wen-Fei He,

Affiliation BioChain (Beijing) Science and Technology Inc., Beijing, China
⨯
Yanxia Zhang,

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Chang Liu,

Affiliations Prenatal Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Maternal and Children Metabolic-Genetic Key Laboratory, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Sujian Xia,

Affiliation Department of Epidemiology, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Qingshan Chen,

Affiliation Department of Health Statistics, Medical College, Jinan University, Guangzhou, Guangdong, China
⨯
Qingguo Zhao,

Affiliations Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China, Department of Healthcare, Guangdong Women And Children Hospital, Guangzhou, Guangdong, China
⨯
[ ... ],
Xiaozhuang Zhang

* E-mail: zhangxiaozhuang55@126.com

Affiliation Thalassemia Diagnosis Centre, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
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The Prevalence and Molecular Spectrum of α- and β-Globin Gene Mutations in 14,332 Families of Guangdong Province, China

Aihua Yin,
Bing Li,
Mingyong Luo,
Longchang Xu,
Li Wu,
Liang Zhang,
Yuanzhu Ma,
Tingting Chen,
Shuang Gao,
Juqing Liang

Published: February 27, 2014
https://doi.org/10.1371/journal.pone.0089855

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