Zscan4 Is Regulated by PI3-Kinase and DNA-Damaging Agents and Directly Interacts with the Transcriptional Repressors LSD1 and CtBP2 in Mouse Embryonic Stem Cells

Michael P. Storm; Benjamin Kumpfmueller; Heather K. Bone; Michael Buchholz; Yolanda Sanchez Ripoll; Julian B. Chaudhuri; Hitoshi Niwa; David Tosh; Melanie J. Welham

doi:10.1371/journal.pone.0089821

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Peer-reviewed

Research Article

Zscan4 Is Regulated by PI3-Kinase and DNA-Damaging Agents and Directly Interacts with the Transcriptional Repressors LSD1 and CtBP2 in Mouse Embryonic Stem Cells

Michael P. Storm ,

Contributed equally to this work with: Michael P. Storm, Benjamin Kumpfmueller

Affiliation Centre for Regenerative Medicine and Departments of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯
Benjamin Kumpfmueller ,

Contributed equally to this work with: Michael P. Storm, Benjamin Kumpfmueller

Affiliations Centre for Regenerative Medicine and Departments of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom, Department of Chemical Engineering, University of Bath, Bath, United Kingdom
⨯
Heather K. Bone,

Affiliation Centre for Regenerative Medicine and Departments of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯
Michael Buchholz,

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
⨯
Yolanda Sanchez Ripoll,

Affiliation Centre for Regenerative Medicine and Departments of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯
Julian B. Chaudhuri,

Affiliation Department of Chemical Engineering, University of Bath, Bath, United Kingdom
⨯
Hitoshi Niwa,

Affiliation RIKEN Centre for Developmental Biology, Kobe, Hyogo, Japan
⨯
David Tosh,

Affiliation Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
⨯
Melanie J. Welham

* E-mail: M.J.Welham@bath.ac.uk

Current address: Biotechnology and Biological Sciences Research Council, Polaris House, Swindon, United Kingdom

Affiliation Centre for Regenerative Medicine and Departments of Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom
⨯

Zscan4 Is Regulated by PI3-Kinase and DNA-Damaging Agents and Directly Interacts with the Transcriptional Repressors LSD1 and CtBP2 in Mouse Embryonic Stem Cells

Michael P. Storm,
Benjamin Kumpfmueller,
Heather K. Bone,
Michael Buchholz,
Yolanda Sanchez Ripoll,
Julian B. Chaudhuri,
Hitoshi Niwa,
David Tosh,
Melanie J. Welham

Published: March 3, 2014
https://doi.org/10.1371/journal.pone.0089821

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Immunoprecipitation
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Immunoblotting
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Cell cycle and cell division
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Protein expression
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Transcriptional control
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Pluripotency
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DNA damage
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Cloning
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