Recruitment of Cbl-b to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes

Margaret Veselits; Azusa Tanaka; Stanley Lipkowitz; Shannon O'Neill; Roger Sciammas; Alison Finnegan; Jian Zhang; Marcus R. Clark

doi:10.1371/journal.pone.0089792

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Peer-reviewed

Research Article

Recruitment of Cbl-b to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes

Margaret Veselits,

Affiliation Section of Rheumatology, Department of Medicine and Knapp Center for Lupus and Immunological Research, University of Chicago, Chicago, Illinois, United States of America
⨯
Azusa Tanaka,

Affiliation Section of Rheumatology, Department of Medicine and Knapp Center for Lupus and Immunological Research, University of Chicago, Chicago, Illinois, United States of America
⨯
Stanley Lipkowitz,

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Shannon O'Neill,

Affiliation Integrated Department of Immunology, National Jewish Medical and Research Center and University of Colorado and Health Sciences Center, Denver, Colorado, United States of America
⨯
Roger Sciammas,

Affiliation Section of Rheumatology, Department of Medicine and Knapp Center for Lupus and Immunological Research, University of Chicago, Chicago, Illinois, United States of America
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Alison Finnegan,

Affiliation Department of Immunology and Microbiology, and Department of Internal Medicine, Section of Rheumatology, Rush University Medical Center, Chicago, Illinois, United States of America
⨯
Jian Zhang,

Affiliation Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
⨯
Marcus R. Clark

* E-mail: mclark@medicine.bsd.uchicago.edu

Affiliation Section of Rheumatology, Department of Medicine and Knapp Center for Lupus and Immunological Research, University of Chicago, Chicago, Illinois, United States of America
⨯

Recruitment of Cbl-b to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes

Margaret Veselits,
Azusa Tanaka,
Stanley Lipkowitz,
Shannon O'Neill,
Roger Sciammas,
Alison Finnegan,
Jian Zhang,
Marcus R. Clark

Published: March 20, 2014
https://doi.org/10.1371/journal.pone.0089792

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B cells
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Endosomes
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Toll-like receptors
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Confocal microscopy
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B cell receptors
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Immunoprecipitation
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T cell receptors
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Ubiquitination
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