MAP3K8 (TPL2/COT) Affects Obesity-Induced Adipose Tissue Inflammation without Systemic Effects in Humans and in Mice

• Dov B. Ballak ,

  Contributed equally to this work with: Dov B. Ballak, Peter van Essen

  Affiliations Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands, Institute for Genomic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infection Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Peter van Essen ,

  Contributed equally to this work with: Dov B. Ballak, Peter van Essen

  Affiliations Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands, Institute for Genomic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Janna A. van Diepen,

  Affiliations Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands, Institute for Genomic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Henry Jansen,

  Affiliation Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Anneke Hijmans,

  Affiliation Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Tetsuya Matsuguchi,

  Affiliation Department of Oral Biochemistry, Field of Developmental Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan

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• Helmut Sparrer,

  Affiliation Novartis Pharma AG, Basel, Switzerland

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• Cees J. Tack,

  Affiliation Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Mihai G. Netea,

  Affiliations Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infection Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Leo A. B. Joosten ,

  ¶These authors share senior authorship.

  Affiliations Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands, Nijmegen Institute for Infection Inflammation and Immunity, Radboud University Medical Centre, Nijmegen, The Netherlands

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• Rinke Stienstra

  * E-mail: rinke.stienstra@radboudumc.nl

  ¶These authors share senior authorship.

  Affiliations Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands, Institute for Genomic and Metabolic Disease, Radboud University Medical Centre, Nijmegen, The Netherlands, Department of Human Nutrition, Wageningen University and Research Centre, Wageningen, The Netherlands

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