Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes

Nora M. Kochupurakkal; Annie J. Kruger; Sudipta Tripathi; Bing Zhu; La Tonya Adams; Daniel B. Rainbow; Aldo Rossini; Dale L. Greiner; Mohamed H. Sayegh; Linda S. Wicker; Indira Guleria

doi:10.1371/journal.pone.0089561

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Peer-reviewed

Research Article

Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes

Nora M. Kochupurakkal,

Affiliation Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School Renal Division, Boston, Massachusetts, United States of America
⨯
Annie J. Kruger,

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Sudipta Tripathi,

Affiliation Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School Renal Division, Boston, Massachusetts, United States of America
⨯
Bing Zhu,

Affiliation Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, United States of America
⨯
La Tonya Adams,

Affiliation Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School Renal Division, Boston, Massachusetts, United States of America
⨯
Daniel B. Rainbow,

Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Aldo Rossini,

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Dale L. Greiner,

Affiliation Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Mohamed H. Sayegh,

Affiliation Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School Renal Division, Boston, Massachusetts, United States of America
⨯
Linda S. Wicker,

Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
⨯
Indira Guleria

* E-mail: Indira.Guleria@childrens.harvard.edu

Affiliation Transplantation Research Center, Brigham and Women's Hospital and Children's Hospital Boston, Harvard Medical School Renal Division, Boston, Massachusetts, United States of America
⨯

Blockade of the Programmed Death-1 (PD1) Pathway Undermines Potent Genetic Protection from Type 1 Diabetes

Nora M. Kochupurakkal,
Annie J. Kruger,
Sudipta Tripathi,
Bing Zhu,
La Tonya Adams,
Daniel B. Rainbow,
Aldo Rossini,
Dale L. Greiner,
Mohamed H. Sayegh,
Linda S. Wicker

Published: February 28, 2014
https://doi.org/10.1371/journal.pone.0089561

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