Activating FLT3 Mutants Show Distinct Gain-of-Function Phenotypes In Vitro and a Characteristic Signaling Pathway Profile Associated with Prognosis in Acute Myeloid Leukemia

Hanna Janke; Friederike Pastore; Daniela Schumacher; Tobias Herold; Karl-Peter Hopfner; Stephanie Schneider; Wolfgang E. Berdel; Thomas Büchner; Bernhard J. Woermann; Marion Subklewe; Stefan K. Bohlander; Wolfgang Hiddemann; Karsten Spiekermann; Harald Polzer

doi:10.1371/journal.pone.0089560

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Open Access

Peer-reviewed

Research Article

Activating FLT3 Mutants Show Distinct Gain-of-Function Phenotypes In Vitro and a Characteristic Signaling Pathway Profile Associated with Prognosis in Acute Myeloid Leukemia

Hanna Janke ,

* E-mail: Hanna.Janke@med.uni-muenchen.de

Affiliations Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany, Clinical Cooperative Group Leukemia, Helmholtz Center Munich, Germany
⨯
Friederike Pastore,

Affiliations Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany, Clinical Cooperative Group Leukemia, Helmholtz Center Munich, Germany, German Cancer Consortium (DKTK), Heidelberg, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Daniela Schumacher,

Affiliation Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany
⨯
Tobias Herold,

Affiliations Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany, Clinical Cooperative Group Leukemia, Helmholtz Center Munich, Germany
⨯
Karl-Peter Hopfner,

Affiliation Department of Biochemistry, Gene Center, Ludwig-Maximilians-University Munich, Germany
⨯
Stephanie Schneider,

Affiliation Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany
⨯
Wolfgang E. Berdel,

Affiliation Department of Medicine A, Hematology, Oncology and Pneumology, University Muenster, Germany
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Thomas Büchner,

Affiliation Department of Medicine A, Hematology, Oncology and Pneumology, University Muenster, Germany
⨯
Bernhard J. Woermann,

Affiliation German Society of Hematology and Oncology, Berlin, Germany
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Marion Subklewe,

Affiliations Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany, German Cancer Consortium (DKTK), Heidelberg, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany, Clinical Cooperative Group Immunotherapy, Helmholtz Center Munich, Germany
⨯
Stefan K. Bohlander,

Affiliation Department of Molecular Medicine and Pathology, University of Auckland, New Zealand
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Wolfgang Hiddemann,

Affiliations Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany, Clinical Cooperative Group Leukemia, Helmholtz Center Munich, Germany, German Cancer Consortium (DKTK), Heidelberg, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Karsten Spiekermann ,

Contributed equally to this work with: Karsten Spiekermann, Harald Polzer

Affiliations Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany, Clinical Cooperative Group Leukemia, Helmholtz Center Munich, Germany, German Cancer Consortium (DKTK), Heidelberg, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯
Harald Polzer

Contributed equally to this work with: Karsten Spiekermann, Harald Polzer

Affiliations Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians-University Munich, Germany, Clinical Cooperative Group Leukemia, Helmholtz Center Munich, Germany, German Cancer Consortium (DKTK), Heidelberg, Germany, German Cancer Research Center (DKFZ), Heidelberg, Germany
⨯

Activating FLT3 Mutants Show Distinct Gain-of-Function Phenotypes In Vitro and a Characteristic Signaling Pathway Profile Associated with Prognosis in Acute Myeloid Leukemia

Hanna Janke,
Friederike Pastore,
Daniela Schumacher,
Tobias Herold,
Karl-Peter Hopfner,
Stephanie Schneider,
Wolfgang E. Berdel,
Thomas Büchner,
Bernhard J. Woermann,
Marion Subklewe

Published: March 7, 2014
https://doi.org/10.1371/journal.pone.0089560

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