Imbalanced Expression of Vcan mRNA Splice Form Proteins Alters Heart Morphology and Cellular Protein Profiles

Tara A. Burns; Maria T. Dours-Zimmermann; Dieter R. Zimmermann; Edward L. Krug; Susana Comte-Walters; Leticia Reyes; Monica A. Davis; Kevin L. Schey; John H. Schwacke; Christine B. Kern; Corey H. Mjaatvedt

doi:10.1371/journal.pone.0089133

Loading metrics

Open Access

Peer-reviewed

Research Article

Imbalanced Expression of Vcan mRNA Splice Form Proteins Alters Heart Morphology and Cellular Protein Profiles

Tara A. Burns,

Affiliation Departments of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Maria T. Dours-Zimmermann,

Affiliation Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
⨯
Dieter R. Zimmermann,

Affiliation Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
⨯
Edward L. Krug,

Affiliation Departments of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Susana Comte-Walters,

Affiliation Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Leticia Reyes,

Affiliation Departments of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Monica A. Davis,

Affiliation Departments of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Kevin L. Schey,

Affiliation Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
John H. Schwacke,

Affiliation Departments of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Christine B. Kern,

Affiliation Departments of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯
Corey H. Mjaatvedt

* E-mail: mjaatvch@musc.edu

Affiliation Departments of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
⨯

Imbalanced Expression of Vcan mRNA Splice Form Proteins Alters Heart Morphology and Cellular Protein Profiles

Tara A. Burns,
Maria T. Dours-Zimmermann,
Dieter R. Zimmermann,
Edward L. Krug,
Susana Comte-Walters,
Leticia Reyes,
Monica A. Davis,
Kevin L. Schey,
John H. Schwacke,
Christine B. Kern

Published: February 20, 2014
https://doi.org/10.1371/journal.pone.0089133

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Extracellular matrix proteins
Is the Subject Area "Extracellular matrix proteins" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Ventricular septal defects
Is the Subject Area "Ventricular septal defects" applicable to this article?

Thanks for your feedback.
Extracellular matrix
Is the Subject Area "Extracellular matrix" applicable to this article?

Thanks for your feedback.
Cardiac ventricles
Is the Subject Area "Cardiac ventricles" applicable to this article?

Thanks for your feedback.
Homozygosity
Is the Subject Area "Homozygosity" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.