Image-Derived Input Function Derived from a Supervised Clustering Algorithm: Methodology and Validation in a Clinical Protocol Using [11C](R)-Rolipram

Chul Hyoung Lyoo; Paolo Zanotti-Fregonara; Sami S. Zoghbi; Jeih-San Liow; Rong Xu; Victor W. Pike; Carlos A. Zarate Jr; Masahiro Fujita; Robert B. Innis

doi:10.1371/journal.pone.0089101

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Open Access

Peer-reviewed

Research Article

Image-Derived Input Function Derived from a Supervised Clustering Algorithm: Methodology and Validation in a Clinical Protocol Using [¹¹C](R)-Rolipram

Chul Hyoung Lyoo ,

Contributed equally to this work with: Chul Hyoung Lyoo, Paolo Zanotti-Fregonara

Affiliation Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
⨯
Paolo Zanotti-Fregonara ,

Contributed equally to this work with: Chul Hyoung Lyoo, Paolo Zanotti-Fregonara

Affiliations Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America, University of Bordeaux, CNRS, INCIA, UMR 5287, Talence, France
⨯
Sami S. Zoghbi,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jeih-San Liow,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Rong Xu,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Victor W. Pike,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Carlos A. Zarate Jr,

Affiliation Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Masahiro Fujita,

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Robert B. Innis

* E-mail: robert.innis@nih.gov

Affiliation Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Image-Derived Input Function Derived from a Supervised Clustering Algorithm: Methodology and Validation in a Clinical Protocol Using [¹¹C](R)-Rolipram

Chul Hyoung Lyoo,
Paolo Zanotti-Fregonara,
Sami S. Zoghbi,
Jeih-San Liow,
Rong Xu,
Victor W. Pike,
Carlos A. Zarate Jr,
Masahiro Fujita,
Robert B. Innis

Published: February 20, 2014
https://doi.org/10.1371/journal.pone.0089101

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