A Functional Polymorphism in the Promoter Region of MicroRNA-146a Is Associated with the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Patients

Lili Cui; You Li; Guoda Ma; Yan Wang; Yujie Cai; Shengyuan Liu; Yanyan Chen; Jia Li; Yuliu Xie; Gen Liu; Bin Zhao; Keshen Li

doi:10.1371/journal.pone.0089019

Loading metrics

Open Access

Peer-reviewed

Research Article

A Functional Polymorphism in the Promoter Region of MicroRNA-146a Is Associated with the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Patients

Lili Cui ,

Contributed equally to this work with: Lili Cui, You Li

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
You Li ,

Contributed equally to this work with: Lili Cui, You Li

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Guoda Ma,

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Yan Wang,

Affiliation Clinical Research Center of Guangdong Medical College, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Yujie Cai,

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Shengyuan Liu,

Affiliation Department of Chronic Disease, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, PR China
⨯
Yanyan Chen,

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Jia Li,

Affiliation Intensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Yuliu Xie,

Affiliation Intensive Care Unit, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Gen Liu,

Affiliations Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Bin Zhao ,

* E-mail: binzhao0759@163.com (BZ); likeshen1971@126.com (KSL)

Affiliations Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China, Institute of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯
Keshen Li

* E-mail: binzhao0759@163.com (BZ); likeshen1971@126.com (KSL)

Affiliation Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, PR China
⨯

A Functional Polymorphism in the Promoter Region of MicroRNA-146a Is Associated with the Risk of Alzheimer Disease and the Rate of Cognitive Decline in Patients

Lili Cui,
You Li,
Guoda Ma,
Yan Wang,
Yujie Cai,
Shengyuan Liu,
Yanyan Chen,
Jia Li,
Yuliu Xie,
Gen Liu

Published: February 25, 2014
https://doi.org/10.1371/journal.pone.0089019

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Alzheimer's disease
Is the Subject Area "Alzheimer's disease" applicable to this article?

Thanks for your feedback.
Variant genotypes
Is the Subject Area "Variant genotypes" applicable to this article?

Thanks for your feedback.
Single nucleotide polymorphisms
Is the Subject Area "Single nucleotide polymorphisms" applicable to this article?

Thanks for your feedback.
Alleles
Is the Subject Area "Alleles" applicable to this article?

Thanks for your feedback.
Medical risk factors
Is the Subject Area "Medical risk factors" applicable to this article?

Thanks for your feedback.
Cognitive impairment
Is the Subject Area "Cognitive impairment" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
MicroRNAs
Is the Subject Area "MicroRNAs" applicable to this article?

Thanks for your feedback.