Thiol/Redox Metabolomic Profiling Implicates GSH Dysregulation in Early Experimental Graft versus Host Disease (GVHD)

Jung H. Suh; Bindu Kanathezhath; Swapna Shenvi; Hua Guo; Alicia Zhou; Anureet Tiwana; Frans Kuypers; Bruce N. Ames; Mark C. Walters

doi:10.1371/journal.pone.0088868

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Open Access

Peer-reviewed

Research Article

Thiol/Redox Metabolomic Profiling Implicates GSH Dysregulation in Early Experimental Graft versus Host Disease (GVHD)

Jung H. Suh ,

* E-mail: jsuh@chori.org (JHS); mwalters@mail.cho.org (MCW)

Affiliation Children’s Hospital Oakland Research Institute, Oakland, California, United States of America
⨯
Bindu Kanathezhath,

Affiliations Children’s Hospital and Research Center Oakland, Oakland, California, United States of America, Division of Blood and Marrow Transplantation, Children’s Hospital and Research Center Oakland, Oakland, California, United States of America
⨯
Swapna Shenvi,

Affiliation Children’s Hospital Oakland Research Institute, Oakland, California, United States of America
⨯
Hua Guo,

Affiliations Children’s Hospital and Research Center Oakland, Oakland, California, United States of America, Department of Pathology, Children’s Hospital and Research Center Oakland, Oakland, California, United States of America
⨯
Alicia Zhou,

Affiliation Children’s Hospital Oakland Research Institute, Oakland, California, United States of America
⨯
Anureet Tiwana,

Affiliation Children’s Hospital Oakland Research Institute, Oakland, California, United States of America
⨯
Frans Kuypers,

Affiliation Children’s Hospital Oakland Research Institute, Oakland, California, United States of America
⨯
Bruce N. Ames,

Affiliation Children’s Hospital Oakland Research Institute, Oakland, California, United States of America
⨯
Mark C. Walters

* E-mail: jsuh@chori.org (JHS); mwalters@mail.cho.org (MCW)

Affiliations Children’s Hospital and Research Center Oakland, Oakland, California, United States of America, Division of Blood and Marrow Transplantation, Children’s Hospital and Research Center Oakland, Oakland, California, United States of America
⨯

Thiol/Redox Metabolomic Profiling Implicates GSH Dysregulation in Early Experimental Graft versus Host Disease (GVHD)

Jung H. Suh,
Bindu Kanathezhath,
Swapna Shenvi,
Hua Guo,
Alicia Zhou,
Anureet Tiwana,
Frans Kuypers,
Bruce N. Ames,
Mark C. Walters

Published: February 18, 2014
https://doi.org/10.1371/journal.pone.0088868

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Oxidation-reduction reactions
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Oxidative stress
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Metabolites
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Bone marrow transplantation
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T cells
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Metabolomics
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