Single-Cell Resolution Imaging of Retinal Ganglion Cell Apoptosis In Vivo Using a Cell-Penetrating Caspase-Activatable Peptide Probe

Xudong Qiu; James R. Johnson; Bradley S. Wilson; Seth T. Gammon; David Piwnica-Worms; Edward M. Barnett

doi:10.1371/journal.pone.0088855

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Peer-reviewed

Research Article

Single-Cell Resolution Imaging of Retinal Ganglion Cell Apoptosis In Vivo Using a Cell-Penetrating Caspase-Activatable Peptide Probe

Xudong Qiu,

Affiliations Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America, Molecular Imaging Center, Mallinckrodt Institute of Radiology, BRIGHT Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
James R. Johnson,

Affiliation Molecular Imaging Center, Mallinckrodt Institute of Radiology, BRIGHT Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Bradley S. Wilson,

Affiliation Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Seth T. Gammon,

Affiliation Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
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David Piwnica-Worms ,

* E-mail: dpiwnica-worms@mdanderson.org (DP-W); embarnett@eyeboston.com (EB)

Affiliations Molecular Imaging Center, Mallinckrodt Institute of Radiology, BRIGHT Institute, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Edward M. Barnett

* E-mail: dpiwnica-worms@mdanderson.org (DP-W); embarnett@eyeboston.com (EB)

Affiliation Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Single-Cell Resolution Imaging of Retinal Ganglion Cell Apoptosis In Vivo Using a Cell-Penetrating Caspase-Activatable Peptide Probe

Xudong Qiu,
James R. Johnson,
Bradley S. Wilson,
Seth T. Gammon,
David Piwnica-Worms,
Edward M. Barnett

Published: February 21, 2014
https://doi.org/10.1371/journal.pone.0088855

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Retina
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