Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease

Sumit Punj; Prasad Kopparapu; Hyo Sang Jang; Jessica L. Phillips; Jamie Pennington; Diana Rohlman; Edmond O’Donnell; Patrick L. Iversen; Siva Kumar Kolluri; Nancy I. Kerkvliet

doi:10.1371/journal.pone.0088726

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Research Article

Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease

Sumit Punj,

Affiliation Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
⨯
Prasad Kopparapu,

Affiliation Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
⨯
Hyo Sang Jang,

Affiliation Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
⨯
Jessica L. Phillips,

Affiliation Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
⨯
Jamie Pennington,

Affiliation Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
⨯
Diana Rohlman,

Affiliation Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
⨯
Edmond O’Donnell,

Affiliation Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
⨯
Patrick L. Iversen,

Affiliation Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America
⨯
Siva Kumar Kolluri,

Affiliations Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon, United States of America
⨯
Nancy I. Kerkvliet

* E-mail: Nancy.kerkvliet@oregonstate.edu

Affiliations Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, Oregon, United States of America, Environmental Health Sciences Center, Oregon State University, Corvallis, Oregon, United States of America
⨯

Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease

Sumit Punj,
Prasad Kopparapu,
Hyo Sang Jang,
Jessica L. Phillips,
Jamie Pennington,
Diana Rohlman,
Edmond O’Donnell,
Patrick L. Iversen,
Siva Kumar Kolluri,
Nancy I. Kerkvliet

Published: February 19, 2014
https://doi.org/10.1371/journal.pone.0088726

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