A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

Alba Llop-Guevara; Derek K. Chu; Tina D. Walker; Susanna Goncharova; Ramzi Fattouh; Jonathan S. Silver; Cheryl Lynn Moore; Juliana L. Xie; Paul M. O’Byrne; Anthony J. Coyle; Roland Kolbeck; Alison A. Humbles; Martin R. Stämpfli; Manel Jordana

doi:10.1371/journal.pone.0088714

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Open Access

Peer-reviewed

Research Article

A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

Alba Llop-Guevara,

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
⨯
Derek K. Chu,

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
⨯
Tina D. Walker,

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
⨯
Susanna Goncharova,

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
⨯
Ramzi Fattouh,

Current address: The Hospital for Sick Children (Sick Kids), Toronto, Ontario, Canada

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
⨯
Jonathan S. Silver,

Affiliation Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Cheryl Lynn Moore,

Current address: Rollins School of Public Health, Atlanta, Georgia, United States of America

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
⨯
Juliana L. Xie,

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
⨯
Paul M. O’Byrne,

Affiliation Department of Medicine, McMaster University, Hamilton, Ontario, Canada
⨯
Anthony J. Coyle,

Affiliations Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada, Pfizer, Cambridge, Massachusetts, United States of America
⨯
Roland Kolbeck,

Affiliation Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Alison A. Humbles,

Affiliation Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, Maryland, United States of America
⨯
Martin R. Stämpfli,

Affiliations Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
⨯
Manel Jordana

* E-mail: jordanam@mcmaster.ca

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, Ontario, Canada
⨯

A GM-CSF/IL-33 Pathway Facilitates Allergic Airway Responses to Sub-Threshold House Dust Mite Exposure

Alba Llop-Guevara,
Derek K. Chu,
Tina D. Walker,
Susanna Goncharova,
Ramzi Fattouh,
Jonathan S. Silver,
Cheryl Lynn Moore,
Juliana L. Xie,
Paul M. O’Byrne,
Anthony J. Coyle

Published: February 14, 2014
https://doi.org/10.1371/journal.pone.0088714

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