Targeted Inhibition of FAK, PYK2 and BCL-XL Synergistically Enhances Apoptosis in Ovarian Clear Cell Carcinoma Cell Lines

Heejei Yoon; Yoon-La Choi; Ji-Young Song; Ingu Do; So Young Kang; Young-Hyeh Ko; Sangyong Song; Byoung-Gie Kim

doi:10.1371/journal.pone.0088587

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Open Access

Peer-reviewed

Research Article

Targeted Inhibition of FAK, PYK2 and BCL-XL Synergistically Enhances Apoptosis in Ovarian Clear Cell Carcinoma Cell Lines

Heejei Yoon ,

Contributed equally to this work with: Heejei Yoon, Yoon-La Choi

Affiliation Institute for Refractory Cancer Research, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Yoon-La Choi ,

Contributed equally to this work with: Heejei Yoon, Yoon-La Choi

Affiliations Institute for Refractory Cancer Research, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Ji-Young Song,

Affiliation Institute for Refractory Cancer Research, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Ingu Do,

Affiliation Samsung Cancer Research Institute. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
So Young Kang,

Affiliation Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Young-Hyeh Ko,

Affiliations Institute for Refractory Cancer Research, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Samsung Cancer Research Institute. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Sangyong Song,

Affiliation Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯
Byoung-Gie Kim

* E-mail: bgkim@skku.edu.

Affiliation Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
⨯

Targeted Inhibition of FAK, PYK2 and BCL-XL Synergistically Enhances Apoptosis in Ovarian Clear Cell Carcinoma Cell Lines

Heejei Yoon,
Yoon-La Choi,
Ji-Young Song,
Ingu Do,
So Young Kang,
Young-Hyeh Ko,
Sangyong Song,
Byoung-Gie Kim

Published: February 11, 2014
https://doi.org/10.1371/journal.pone.0088587

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Apoptosis
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Ovarian cancer
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Cytotoxicity
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Cancer treatment
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Fluorescence-activated cell sorting
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Apoptotic signaling cascade
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Cell proliferation
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Immunohistochemistry techniques
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