Alanine-glyoxylate aminotransferase 2 (AGXT2) Polymorphisms Have Considerable Impact on Methylarginine and β-aminoisobutyrate Metabolism in Healthy Volunteers

Anja Kittel; Fabian Müller; Jörg König; Maren Mieth; Heinrich Sticht; Oliver Zolk; Ana Kralj; Markus R. Heinrich; Martin F. Fromm; Renke Maas

doi:10.1371/journal.pone.0088544

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Peer-reviewed

Research Article

Alanine-glyoxylate aminotransferase 2 (AGXT2) Polymorphisms Have Considerable Impact on Methylarginine and β-aminoisobutyrate Metabolism in Healthy Volunteers

Anja Kittel ,

Contributed equally to this work with: Anja Kittel, Fabian Müller

Affiliation Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Fabian Müller ,

Contributed equally to this work with: Anja Kittel, Fabian Müller

Affiliation Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Jörg König,

Affiliation Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Maren Mieth,

Affiliation Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Heinrich Sticht,

Affiliation Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Oliver Zolk,

Current address: Institute of Pharmacology of Natural Products & Clinical Pharmacology, Ulm University, Ulm, Germany

Affiliation Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Ana Kralj,

Affiliation Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität, Erlangen-Nürnberg, Erlangen, Germany
⨯
Markus R. Heinrich,

Affiliation Department of Chemistry and Pharmacy, Friedrich-Alexander-Universität, Erlangen-Nürnberg, Erlangen, Germany
⨯
Martin F. Fromm,

Affiliation Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯
Renke Maas

* E-mail: renke.maas@pharmakologie.uni-erlangen.de

Affiliation Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
⨯

Alanine-glyoxylate aminotransferase 2 (AGXT2) Polymorphisms Have Considerable Impact on Methylarginine and β-aminoisobutyrate Metabolism in Healthy Volunteers

Anja Kittel,
Fabian Müller,
Jörg König,
Maren Mieth,
Heinrich Sticht,
Oliver Zolk,
Ana Kralj,
Markus R. Heinrich,
Martin F. Fromm,
Renke Maas

Published: February 24, 2014
https://doi.org/10.1371/journal.pone.0088544

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