TCRγδ+CD4−CD8− T Cells Suppress the CD8+ T-Cell Response to Hepatitis B Virus Peptides, and Are Associated with Viral Control in Chronic Hepatitis B

Qintao Lai; Shiwu Ma; Jun Ge; Zuxiong Huang; Xuan Huang; Xiaotao Jiang; Yongyin Li; Mingxia Zhang; Xiaoyong Zhang; Jian Sun; William G. H. Abbott; Jinlin Hou

doi:10.1371/journal.pone.0088475

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Peer-reviewed

Research Article

TCRγδ⁺CD4⁻CD8⁻ T Cells Suppress the CD8⁺ T-Cell Response to Hepatitis B Virus Peptides, and Are Associated with Viral Control in Chronic Hepatitis B

Qintao Lai,

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯
Shiwu Ma,

Affiliations Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China, Department of Infectious Diseases, Kunming General Hospital of PLA, Kunming, China
⨯
Jun Ge,

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯
Zuxiong Huang,

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯
Xuan Huang,

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯
Xiaotao Jiang,

Affiliations Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China, Department of immunology, Basic Medicine School, Southern Medical University, Auckland City Hospital, Auckland, New Zealand
⨯
Yongyin Li,

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯
Mingxia Zhang,

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯
Xiaoyong Zhang,

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯
Jian Sun,

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯
William G. H. Abbott,

Affiliations Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China, The New Zealand Liver Transplant Unit, Auckland City Hospital, Auckland, New Zealand
⨯
Jinlin Hou

* E-mail: jlhousmu@163.com

Affiliation Hepatology Unit and Key Lab for Organ Failure Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, No. 1838, North Guangzhou Avenue, Guangzhou, China
⨯

TCRγδ⁺CD4⁻CD8⁻ T Cells Suppress the CD8⁺ T-Cell Response to Hepatitis B Virus Peptides, and Are Associated with Viral Control in Chronic Hepatitis B

Qintao Lai,
Shiwu Ma,
Jun Ge,
Zuxiong Huang,
Xuan Huang,
Xiaotao Jiang,
Yongyin Li,
Mingxia Zhang,
Xiaoyong Zhang,
Jian Sun

Published: February 14, 2014
https://doi.org/10.1371/journal.pone.0088475

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