Clobazam and Its Active Metabolite N-desmethylclobazam Display Significantly Greater Affinities for α2- versus α1-GABAA–Receptor Complexes

Open Access

Peer-reviewed

Research Article

Clobazam and Its Active Metabolite N-desmethylclobazam Display Significantly Greater Affinities for α₂- versus α₁-GABA_A–Receptor Complexes

Henrik Sindal Jensen ,

* E-mail: hsin@lundbeck.com

Affiliation Synaptic Transmission, Neuroscience Drug Discovery, H. Lundbeck A/S, Valby, Denmark
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Kathryn Nichol,

Affiliation Medical Affairs, Lundbeck LLC, Deerfield, Illinois, United States of America
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Deborah Lee,

Affiliation Clinical Affairs, Lundbeck LLC, Deerfield, Illinois, United States of America
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Bjarke Ebert

Affiliation Department of Electrophysiology, H. Lundbeck A/S, Valby, Denmark
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Transfection
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Anticonvulsants
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Cell binding
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Diazepam
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Receptor binding assays
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Sedatives
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Binding analysis
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Ligand-gated ion channels
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