High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers

Heather L. Martin; Matthew Adams; Julie Higgins; Jacquelyn Bond; Ewan E. Morrison; Sandra M. Bell; Stuart Warriner; Adam Nelson; Darren C. Tomlinson

doi:10.1371/journal.pone.0088338

Loading metrics

Open Access

Peer-reviewed

Research Article

High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers

Heather L. Martin,

Affiliations BioScreening Technology Group, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom, School of Chemistry, University of Leeds, Leeds, United Kingdom
⨯
Matthew Adams,

Affiliation BioScreening Technology Group, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom
⨯
Julie Higgins,

Affiliation BioScreening Technology Group, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom
⨯
Jacquelyn Bond,

Affiliations BioScreening Technology Group, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom, Section of Ophthalmology and Neuroscience, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom
⨯
Ewan E. Morrison,

Affiliations BioScreening Technology Group, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom, Section of Ophthalmology and Neuroscience, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom
⨯
Sandra M. Bell,

Affiliations BioScreening Technology Group, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom, Section of Ophthalmology and Neuroscience, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom
⨯
Stuart Warriner,

Affiliations School of Chemistry, University of Leeds, Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
⨯
Adam Nelson,

Affiliations School of Chemistry, University of Leeds, Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
⨯
Darren C. Tomlinson

* E-mail: d.c.tomlinson@leeds.ac.uk

Affiliations BioScreening Technology Group, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom, Section of Ophthalmology and Neuroscience, Leeds Institutes of Molecular Medicine, University of Leeds, Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, United Kingdom
⨯

High-Content, High-Throughput Screening for the Identification of Cytotoxic Compounds Based on Cell Morphology and Cell Proliferation Markers

Heather L. Martin,
Matthew Adams,
Julie Higgins,
Jacquelyn Bond,
Ewan E. Morrison,
Sandra M. Bell,
Stuart Warriner,
Adam Nelson,
Darren C. Tomlinson

Published: February 5, 2014
https://doi.org/10.1371/journal.pone.0088338

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Library screening
Is the Subject Area "Library screening" applicable to this article?

Thanks for your feedback.
Cytotoxicity
Is the Subject Area "Cytotoxicity" applicable to this article?

Thanks for your feedback.
Cytotoxicity assay
Is the Subject Area "Cytotoxicity assay" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Image analysis
Is the Subject Area "Image analysis" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Drug screening
Is the Subject Area "Drug screening" applicable to this article?

Thanks for your feedback.
Phenotypes
Is the Subject Area "Phenotypes" applicable to this article?

Thanks for your feedback.