Fusion of Ubiquitin to HIV Gag Impairs Human Monocyte-Derived Dendritic Cell Maturation and Reduces Ability to Induce Gag T Cell Responses

Shanthi Herath; Adel Benlahrech; Timos Papagatsias; Takis Athanasopoulos; Zineb Bouzeboudjen; Catherine Hervouet; Linda Klavinskis; Andrea Meiser; Peter Kelleher; George Dickson; Steven Patterson

doi:10.1371/journal.pone.0088327

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Peer-reviewed

Research Article

Fusion of Ubiquitin to HIV Gag Impairs Human Monocyte-Derived Dendritic Cell Maturation and Reduces Ability to Induce Gag T Cell Responses

Shanthi Herath,

Affiliation Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
⨯
Adel Benlahrech,

Affiliation Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
⨯
Timos Papagatsias,

Affiliation Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
⨯
Takis Athanasopoulos,

Affiliation School of Biological Science, Royal Holloway University of London, Egham, Surrey, United Kingdom
⨯
Zineb Bouzeboudjen,

Affiliation Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
⨯
Catherine Hervouet,

Affiliation Peter Gorer Department of Immunobiology, Guys Hospital, Kings College London, London, United Kingdom
⨯
Linda Klavinskis,

Affiliation Peter Gorer Department of Immunobiology, Guys Hospital, Kings College London, London, United Kingdom
⨯
Andrea Meiser,

Affiliation Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
⨯
Peter Kelleher,

Affiliation Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
⨯
George Dickson,

Affiliation School of Biological Science, Royal Holloway University of London, Egham, Surrey, United Kingdom
⨯
Steven Patterson

* E-mail: s.patterson@imperial.ac.uk

Affiliation Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom
⨯

Fusion of Ubiquitin to HIV Gag Impairs Human Monocyte-Derived Dendritic Cell Maturation and Reduces Ability to Induce Gag T Cell Responses

Shanthi Herath,
Adel Benlahrech,
Timos Papagatsias,
Takis Athanasopoulos,
Zineb Bouzeboudjen,
Catherine Hervouet,
Linda Klavinskis,
Andrea Meiser,
Peter Kelleher,
George Dickson

Published: February 5, 2014
https://doi.org/10.1371/journal.pone.0088327

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Cytotoxic T cells
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Ubiquitination
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HIV
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