Overexpression of Cyclooxygenase-2 in Malignant Peripheral Nerve Sheath Tumor and Selective Cyclooxygenase-2 Inhibitor-Induced Apoptosis by Activating Caspases in Human Malignant Peripheral Nerve Sheath Tumor Cells

Michiyuki Hakozaki; Takahiro Tajino; Shinichi Konno; Shinichi Kikuchi; Hitoshi Yamada; Michiro Yanagisawa; Jun Nishida; Hiroyuki Nagasawa; Takashi Tsuchiya; Akira Ogose; Masafumi Abe; Hiroshi Hojo

doi:10.1371/journal.pone.0088035

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Peer-reviewed

Research Article

Overexpression of Cyclooxygenase-2 in Malignant Peripheral Nerve Sheath Tumor and Selective Cyclooxygenase-2 Inhibitor-Induced Apoptosis by Activating Caspases in Human Malignant Peripheral Nerve Sheath Tumor Cells

Michiyuki Hakozaki ,

* E-mail: paco@fmu.ac.jp

Affiliations Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan, Department of Pathology and Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Takahiro Tajino,

Affiliations Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Shinichi Konno,

Affiliations Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Shinichi Kikuchi,

Affiliation Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
⨯
Hitoshi Yamada,

Affiliations Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Michiro Yanagisawa,

Affiliations Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Aomori, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Jun Nishida,

Affiliations Department of Orthopaedic Surgery, School of Medicine, Iwate Medical University, Iwate, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Hiroyuki Nagasawa,

Affiliations Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Takashi Tsuchiya,

Affiliations Department of Orthopaedic Surgery, Yamagata University Faculty of Medicine, Yamagata, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Akira Ogose,

Affiliations Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Tohoku Musculoskeletal Tumor Society, Yamagata, Japan
⨯
Masafumi Abe,

Affiliation Department of Pathology and Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan
⨯
Hiroshi Hojo

Affiliation Department of Pathology and Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan
⨯

Overexpression of Cyclooxygenase-2 in Malignant Peripheral Nerve Sheath Tumor and Selective Cyclooxygenase-2 Inhibitor-Induced Apoptosis by Activating Caspases in Human Malignant Peripheral Nerve Sheath Tumor Cells

Michiyuki Hakozaki,
Takahiro Tajino,
Shinichi Konno,
Shinichi Kikuchi,
Hitoshi Yamada,
Michiro Yanagisawa,
Jun Nishida,
Hiroyuki Nagasawa,
Takashi Tsuchiya,
Akira Ogose

Published: February 6, 2014
https://doi.org/10.1371/journal.pone.0088035

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